Synthesis and cytotoxic activities of group 3 metal complexes having monoanionic tridentate ligands

Eur J Med Chem. 2010 Sep;45(9):4169-74. doi: 10.1016/j.ejmech.2010.06.008. Epub 2010 Jun 12.

Abstract

Complexes of scandium, yttrium, samarium and neodymium bearing monoanionic tridentate ancillary ligands have been synthesized and characterized. The cytotoxic activities of novel compounds, as well as that of similar compounds previously reported have been evaluated on rat glioma (C6), murine fibrosarcoma (WHEI-164) and human embryonic kidney (HEK-293) cell lines. Scandium complex with quinolinephenoxyamine (NNHO) ligand showed very interesting activity against C6 cell line.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Humans
  • Inhibitory Concentration 50
  • Metals, Rare Earth / chemistry*
  • Mice
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Quinolines / chemistry
  • Rats
  • Spectrum Analysis

Substances

  • Antineoplastic Agents
  • Metals, Rare Earth
  • Organometallic Compounds
  • Quinolines