Genetic study of gutter-shaped root (GSR) in AKXL RI mouse strains using QTL analysis

J Oral Sci. 2010 Jun;52(2):213-20. doi: 10.2334/josnusd.52.213.

Abstract

In this study, quantitative trait locus (QTL) analysis was used to identify candidate chromosomes and for detecting the regions that include the gene or genes causing gutter-shaped root (GSR) in AKXL recombinant inbred mouse strains. One potential QTL was detected on chromosome 5 within a region of 13.0 cM, where the likelihood ratio statistic (LRS) score was higher than a suggestive level. This indicates that one of the candidate genes causing mouse GSR may be located in this region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Female
  • Genetic Markers / genetics
  • Lod Score
  • Male
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Inbred Strains
  • Molar / abnormalities*
  • Phenotype
  • Polymorphism, Genetic / genetics
  • Quantitative Trait Loci / genetics*
  • Recombination, Genetic / genetics
  • Tooth Root / abnormalities*

Substances

  • Genetic Markers