Homo- and heptanor-sterols and tremulane sesquiterpenes from cultures of Phellinus igniarius

J Nat Prod. 2010 Jul 23;73(7):1294-300. doi: 10.1021/np100216k.

Abstract

Four steroids, a homopregnene (1) and three heptanorergosterane derivatives (2-4), nine tremulane sesquiterpenes (5-13), and 18 known compounds have been isolated from cultures of the fungus Phellinus igniarius. Their structures and absolute configurations were elucidated by spectroscopic data analysis. In preliminary in vitro assays, at 10(-5) M, compounds 8, 9, 13, and 3beta-hydroxy-11,12-O-isopropyldrimene (14) showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 35.7%, 45.4%, 46.6%, and 32.1%, respectively, as compared with the blank control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Phenylephrine / pharmacology
  • Polyporaceae / chemistry*
  • Pregnenes / chemistry
  • Pregnenes / isolation & purification*
  • Pregnenes / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Sterols / chemistry
  • Sterols / isolation & purification*
  • Sterols / pharmacology
  • Vasodilator Agents / chemistry
  • Vasodilator Agents / isolation & purification*
  • Vasodilator Agents / pharmacology

Substances

  • 3,17,20-trihydroxy-4-methylpregn-8-en-7-one
  • Pregnenes
  • Sesquiterpenes
  • Sterols
  • Vasodilator Agents
  • phellinignincisterol A
  • phellinignincisterol B
  • phellinignincisterol C
  • Phenylephrine