[Study of the association between catalepsy, anxiety, aggression and depressive-like behavior in congenic mice]

Ross Fiziol Zh Im I M Sechenova. 2010 May;96(5):464-71.
[Article in Russian]

Abstract

Catalepsy is a natural passive defense strategy in animals and a syndrome of some mental di sorders. The main gene encoding catalepsy was located in mice on the distal fragment 55-75 cM of chromosome 13. Two congenic lines AKR.CBA-D13Mit76 and AKR.CBA-D 13Mit78 carrying the 55- to 71-, and 71- to 75-cM fragments of chromosome 13 transferred from the cataleptic strain CBA to the non-cataleptic strain AKR genome were created. It was shown that half of mice of congenic AKR.CBA-D 13 Mit76 line containing fragment 55-71 cM displayed pronounced catalepsy similar to the donor CBA strain. Also we demonstrated decreased of exploratory behavior in the open field test and an increased of intermale aggression of AKR.CBA-D 13Mit76 mice compared with the parent strain AKR. No differences were found in the forced swim test between AKR.CBA-D 13Mit76 and AKR mice. Behavior of congenic mice AKR.CBA-D 13Mit78 did not differ from the parent strain AKR in all used tests.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggression*
  • Animals
  • Anxiety* / genetics
  • Anxiety* / physiopathology
  • Behavior, Animal*
  • Catalepsy* / genetics
  • Catalepsy* / physiopathology
  • Chromosomes, Mammalian / genetics*
  • Depression* / genetics
  • Depression* / physiopathology
  • Male
  • Mice
  • Mice, Congenic
  • Mice, Inbred AKR
  • Mice, Inbred CBA
  • Species Specificity