(99m)Tc-labeled-1-thio-beta-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis

Cláudia Borges Brasileiro; Cinthia Mara da Fonseca Pacheco; Celso Martins Queiroz-Junior; Carla Flávia de Lima; Juliana Batista da Silva; Tarcísio Passos Ribeiro de Campos

doi:10.1016/j.apradiso.2010.06.002

(99m)Tc-labeled-1-thio-beta-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis

Appl Radiat Isot. 2010 Dec;68(12):2261-7. doi: 10.1016/j.apradiso.2010.06.002. Epub 2010 Jun 15.

Authors

Cláudia Borges Brasileiro¹, Cinthia Mara da Fonseca Pacheco, Celso Martins Queiroz-Junior, Carla Flávia de Lima, Juliana Batista da Silva, Tarcísio Passos Ribeiro de Campos

Affiliation

¹ Departamento de Engenharia Nuclear--PCA, Escola de Engenharia, Universidade Federal de Minas Gerais (UFMG)--Avenida Presidente Antônio Carlos, 6627, CEP: 31270-100 Belo Horizonte, MG, Brazil. cbbrasileiro@gmail.com

PMID: 20579894
DOI: 10.1016/j.apradiso.2010.06.002

Abstract

Aim: The aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-beta-d-glucose radiolabeled with technetium-99m.

Method: The method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of (99m)Tc-1-TG and kinetic scintigraphy imaging.

Results: Results show a significant difference of (99m)Tc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of (99m)Tc-1-TG by images showed the kidneys' excretion.

Conclusion: As conclusion, (99m)Tc-1-TG is a helpful tool in TMJ inflammatory process detection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Glucose / administration & dosage*
Glucose / chemistry
Male
Organotechnetium Compounds*
Radiopharmaceuticals*
Rats
Temporomandibular Joint Disorders / diagnosis*

Substances

Organotechnetium Compounds
Radiopharmaceuticals
Glucose