In addition to the myotendinous junctions, muscle fibers also are connected to the extracellular matrix along their full peripheral length. Moreover, within the in vivo context, muscle is not an isolated entity. Instead, myofascial tissues connect muscles mechanically to neighboring muscular and nonmuscular structures, epimuscularly. This paper reviews the key aspects, determinants, and effects of epimuscular myofascial force transmission on muscular mechanics.