Abstract
Amides with quaternary stereogenic centers have been synthesised by catalytic asymmetric vinylogous Mukaiyama aldol reactions. The chiral copper-sulfoximine catalyst gives rise to products with moderate to good yields and up to 92% ee.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Amides / chemical synthesis*
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Amides / chemistry
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Catalysis
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Copper / chemistry
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Stereoisomerism
Substances
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Aldehydes
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Amides
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Copper
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3-hydroxybutanal