To investigate the mechanism of meridians in circulating qi and blood and its role in medical model of TCM. To clarify the cell model of meridian structure formation and the significance in both its mechanism of regulating qi and blood and TCM model formation, by using the result of modern life science researches. With its unique mechanism formation and through its organizational structure, the meridian structure manages to regulate the state of qi and blood circulation in the tissues and organs by affecting the bio-activity and the specific bio-active substance transmission of mast cells, which also plays an important role in the medical model formation of TCM.