Enhanced expression of glutathione S-transferase in the hippocampus following acute treatment with trimethyltin in vivo

J Pharmacol Sci. 2010;113(3):267-70. doi: 10.1254/jphs.09158sc. Epub 2010 Jun 16.

Abstract

We investigated the effects of treatment with trimethyltin (TMT) on the expression of glutathione-related enzymes in mouse hippocampus. TMT promoted the expression of glutathione S-transferase (GST) Ya/Yc mRNA, and GSTA2 protein, but not that of glutamate-cysteine ligase catalytic subunit mRNA, 1 day after injection. TMT produced a slight but significant elevation of GST activity during the period from day 1 to 7 post-treatment. No significant change was seen in the activity of glutathione peroxidase at anytime post-TMT treatment. Our data suggest the prolonged elevation of GST activity in the hippocampus following TMT treatment through enhanced expression of the GST Ya/Yc.

Publication types

  • Historical Article

MeSH terms

  • Animals
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Glutamate-Cysteine Ligase / genetics
  • Glutamate-Cysteine Ligase / metabolism
  • Glutathione / metabolism*
  • Glutathione Peroxidase / metabolism
  • Glutathione Transferase / genetics
  • Glutathione Transferase / metabolism*
  • Hippocampus / drug effects*
  • Hippocampus / enzymology*
  • Hippocampus / metabolism
  • History, 16th Century
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Male
  • Mice
  • Mice, Inbred Strains
  • Oxidants / toxicity*
  • Oxidative Stress / drug effects
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Time Factors
  • Trimethyltin Compounds / toxicity*

Substances

  • Isoenzymes
  • Oxidants
  • RNA, Messenger
  • Trimethyltin Compounds
  • trimethyltin
  • Glutathione Peroxidase
  • glutathione S-transferase Yc
  • Glutathione Transferase
  • glutathione S-transferase alpha
  • Glutamate-Cysteine Ligase
  • Glutathione