Lack of association between interleukin-1 alpha, beta polymorphisms and Parkinson's disease

Abstract

The associations between interleukin-1 alpha (IL-1alpha-889) and beta (IL-1beta-511) single nucleotide polymorphisms (SNPs) and the risk for Parkinson's disease (PD) are still controversial and ambiguous. The aim of this study was to determine a more precise estimation of the relationship by meta-analysis. We searched databases through March 2010 for all publications on the association between these variations and PD. A total of 11 studies including 2803 PD patients and 2539 healthy controls were identified. The overall and geographic subgroups analysis was conducted, and odds ratios (OR) and 95% confidence intervals (95% CI) were calculated in the fixed- or random-effects model. We found that the overall OR (95% CI) for TT and CT genotypes versus CC genotype for IL-1alpha-889 was 1.01 (0.88-1.16), while the overall OR (95% CI) for TT and CT genotypes versus CC genotype for IL-1beta-511 was 1.19 (0.87-1.62). The sensitivity analysis strengthened our confidence in the validity of these null associations. There was no publication bias observed in this study. To sum up, there were no associations found between the SNPs of IL-1alpha-889, IL-1beta-511 and risk for PD.