A new approach for PEGylation of dendrimers

Hemant Khambete; Surya P Gautam; C Karthikeyan; Suman Ramteke; N S Hari Narayana Moorthy; Piyush Trivedi

doi:10.1016/j.bmcl.2010.03.100

A new approach for PEGylation of dendrimers

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4279-81. doi: 10.1016/j.bmcl.2010.03.100. Epub 2010 May 25.

Authors

Hemant Khambete¹, Surya P Gautam, C Karthikeyan, Suman Ramteke, N S Hari Narayana Moorthy, Piyush Trivedi

Affiliation

¹ School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Airport Bypass Road, Gandhi Nagar, Bhopal (MP) 462 036, India.

PMID: 20558063
DOI: 10.1016/j.bmcl.2010.03.100

Abstract

Dendrimers have emerged as one of the most interesting themes for researchers as a result of unique functional architecture and macromolecular characteristics. The reported methods of PEGylation are very time consuming and required multisteps for synthesis. In present work we have synthesized PEGylated polyamidoamine (PAMAM) dendrimers using epichlorohydrin as a linker. The PEGylated dendrimers were evaluated for color reaction UV, IR and NMR studies and compared with standard data.

2010. Published by Elsevier Ltd.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dendrimers*
Polyethylene Glycols / chemistry*
Spectrum Analysis / methods

Substances

Dendrimers
Polyethylene Glycols