7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata

Rohan A Davis; Ozlem Demirkiran; Melissa L Sykes; Vicky M Avery; Lekha Suraweera; Gregory A Fechner; Ronald J Quinn

doi:10.1016/j.bmcl.2010.05.091

7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4057-9. doi: 10.1016/j.bmcl.2010.05.091. Epub 2010 May 25.

Authors

Rohan A Davis¹, Ozlem Demirkiran, Melissa L Sykes, Vicky M Avery, Lekha Suraweera, Gregory A Fechner, Ronald J Quinn

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.

PMID: 20558060
DOI: 10.1016/j.bmcl.2010.05.091

Abstract

Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Humans
Lactones / chemistry
Lactones / pharmacology*
Pyrones / chemistry
Pyrones / pharmacology*
Trypanocidal Agents / isolation & purification
Trypanocidal Agents / pharmacology*

Substances

7',8'-dihydroobolactone
Lactones
Pyrones
Trypanocidal Agents