Abstract
sp(2)-Iminosugar-type castanospermine analogues bearing an alpha-configured N-, S-, or C-linked pseudoanomeric group have been designed as selective inhibitors of the neutral alpha-glucosidases involved in N-glycoprotein processing; evaluation in breast cancer cell growth indicated a significant antiproliferative potential that was dependent on the nature of the pseudoanomeric group.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Glycoside Hydrolase Inhibitors*
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Glycosides / chemistry*
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Humans
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Indolizines / chemistry*
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Indolizines / pharmacology
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Molecular Structure
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Monosaccharides / chemistry*
Substances
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Antineoplastic Agents
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C-glycoside
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Glycosides
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Indolizines
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Monosaccharides
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castanospermine