Chemical constituents from Delphinium chrysotrichum and their biological activity

Fitoterapia. 2010 Oct;81(7):929-31. doi: 10.1016/j.fitote.2010.06.008. Epub 2010 Jun 13.

Abstract

A new diterpene alkaloid named delphatisine C (1) has been isolated from aerial parts of Delphinium chrysotrichum along with three known norditerpenoid alkaloids delpheline (2), delbrunine (3), and delectinine (4). Their structures were characterized on the basis of their spectral data. All of them were determined by SRB assay for their cytotoxicity, and compound (1) showed significant cytotoxic activities (IC(50)=2.36 μmol/L) against the A549 cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Alkaloids / therapeutic use
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Cell Line, Tumor
  • Delphinium / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Diterpenes / therapeutic use*
  • Humans
  • Lung Neoplasms / drug therapy*
  • Molecular Structure
  • Phytotherapy*
  • Plant Components, Aerial
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use*

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Plant Extracts
  • delphatisine C