Hypoxia and metastasis in breast cancer

Helene Rundqvist; Randall S Johnson

doi:10.1007/82_2010_77

Hypoxia and metastasis in breast cancer

Curr Top Microbiol Immunol. 2010:345:121-39. doi: 10.1007/82_2010_77.

Authors

Helene Rundqvist¹, Randall S Johnson

Affiliation

¹ Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, CA 92093, USA.

PMID: 20549469
DOI: 10.1007/82_2010_77

Abstract

In this review we summarize the evidence for a role for hypoxic response in the biology of metastasis, with a particular emphasis on the metastasis of breast cancer and the function of the hypoxia inducible factor (HIF).

Publication types

Review

MeSH terms

Basic Helix-Loop-Helix Transcription Factors / physiology
Breast Neoplasms / metabolism
Breast Neoplasms / pathology*
Cell Hypoxia*
Female
Humans
Hypoxia-Inducible Factor 1 / physiology
Neoplasm Metastasis

Substances

Basic Helix-Loop-Helix Transcription Factors
Hypoxia-Inducible Factor 1
endothelial PAS domain-containing protein 1