Abstract
On the isolated frog heart alpha- and gamma-endorphins depressed the chronotropic effects of exogenous acetylcholine. Naloxone partially blocked the atropine-like action of alpha-, gamma-endorphins. The latent period of the reaction to the endorphin injection was about 20 min, the endorphin effect retained more than 1 h. The obtained data show that some opioids may act as "endogenous atropine".
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Acetylcholine / antagonists & inhibitors*
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Acetylcholine / pharmacology
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Animals
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Depression, Chemical
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Dose-Response Relationship, Drug
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Endorphins / antagonists & inhibitors
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Endorphins / pharmacology*
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Heart Rate / drug effects*
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In Vitro Techniques
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Naloxone / pharmacology
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beta-Endorphin / pharmacology
Substances
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Endorphins
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Naloxone
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beta-Endorphin
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Acetylcholine