Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4206-9. doi: 10.1016/j.bmcl.2010.05.044. Epub 2010 May 19.

Abstract

We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetone / analogs & derivatives*
  • Acetone / chemistry
  • Acetone / pharmacology
  • Animals
  • Basilar Artery / drug effects
  • Basilar Artery / physiology
  • Marine Biology*
  • Rabbits
  • Vasodilator Agents / chemical synthesis*
  • Vasodilator Agents / pharmacology

Substances

  • Vasodilator Agents
  • Acetone