Abstract
Rottlerin is a natural polyphenolic compound, which was initially indicated and marketed as a PKC delta inhibitor and recently proposed and patented as an anti-hypertensive drug. In vitro results from our Laboratory and data from the literature suggest a potential use of Rottlerin in the treatment/control of psoriasis, a skin disease characterized by abnormal cellular proliferation, abnormal angiogenesis and inflammation. Rottlerin, indeed, is an antioxidant and a potent inhibitor of the transcription factor NFkappaB, a key mediator of immune responses and a crucial regulator of cell cycle and apoptosis in immune cells, endothelial cells and keratinocytes. Herein, we will review the multiple activities of Rottlerin (antioxidant, antiproliferative, antiangiogenic and anti-inflammatory) that give to the drug the potential to be used as a new therapeutic approach against psoriasis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acetophenones / chemistry
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Acetophenones / pharmacology*
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Acetophenones / therapeutic use*
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Angiogenesis Inhibitors / chemistry
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Angiogenesis Inhibitors / pharmacology
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Antioxidants / chemistry
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Antioxidants / pharmacology
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Antioxidants / therapeutic use
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Benzopyrans / therapeutic use*
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Cell Proliferation / drug effects
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Drug Discovery
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Humans
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Keratinocytes / drug effects
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Keratinocytes / metabolism
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NF-kappa B / antagonists & inhibitors
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Neovascularization, Pathologic / drug therapy
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Neovascularization, Pathologic / metabolism
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Oxidative Stress / drug effects
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Phytotherapy
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Protein Kinase Inhibitors / chemistry
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Protein Kinase Inhibitors / pharmacology*
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Protein Kinase Inhibitors / therapeutic use*
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Psoriasis / drug therapy*
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Psoriasis / metabolism
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Psoriasis / physiopathology
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Reactive Oxygen Species / chemistry
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Reactive Oxygen Species / metabolism
Substances
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Acetophenones
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Angiogenesis Inhibitors
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Benzopyrans
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NF-kappa B
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Protein Kinase Inhibitors
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Reactive Oxygen Species
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rottlerin