Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid

René Csuk; Anja Niesen-Barthel; Alexander Barthel; Ralph Kluge; Dieter Ströhl

doi:10.1016/j.ejmech.2010.05.036

Synthesis of an antitumor active endoperoxide from 11-keto-beta-boswellic acid

Eur J Med Chem. 2010 Sep;45(9):3840-3. doi: 10.1016/j.ejmech.2010.05.036. Epub 2010 May 24.

Authors

René Csuk¹, Anja Niesen-Barthel, Alexander Barthel, Ralph Kluge, Dieter Ströhl

Affiliation

¹ Bereich Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. rene.csuk@chemie.uni-halle.de

PMID: 20538386
DOI: 10.1016/j.ejmech.2010.05.036

Abstract

An endoperoxide was synthesized starting from 11-keto-beta-boswellic acid and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The compound induces apoptosis and shows an average IC(50) value of 0.4-4.5 microM.

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Triterpenes / chemical synthesis*
Triterpenes / chemistry
Triterpenes / pharmacology*

Substances

11-keto-boswellic acid
Antineoplastic Agents
Triterpenes