Development of chiral terminal-alkene-phosphine hybrid ligands for palladium-catalyzed asymmetric allylic substitutions

Zhaoqun Liu; Haifeng Du

doi:10.1021/ol101069y

Development of chiral terminal-alkene-phosphine hybrid ligands for palladium-catalyzed asymmetric allylic substitutions

Org Lett. 2010 Jul 2;12(13):3054-7. doi: 10.1021/ol101069y.

Authors

Zhaoqun Liu¹, Haifeng Du

Affiliation

¹ Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

PMID: 20536224
DOI: 10.1021/ol101069y

Abstract

A variety of novel chiral terminal-alkene-phosphine hybrid ligands were successfully developed from diethyl L-tartrate for palladium-catalyzed asymmetric allylic alkylations, etherifications, and amination to give the desired products in excellent yields and ee's.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemical synthesis*
Alkenes / chemistry
Alkylation
Amination
Catalysis
Ligands
Molecular Structure
Organometallic Compounds / chemistry*
Palladium / chemistry*
Phosphines / chemical synthesis*
Phosphines / chemistry
Stereoisomerism

Substances

Alkenes
Ligands
Organometallic Compounds
Phosphines
Palladium