Abstract
TNF-α is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-α triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-α rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-α-induced cell signaling and biological responses is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Enzyme Activation
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Humans
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Inflammation / genetics
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Mice
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Mice, Knockout
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Mice, Transgenic
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Molecular Weight
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Receptors, Tumor Necrosis Factor, Type I / chemistry
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Receptors, Tumor Necrosis Factor, Type I / deficiency
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Receptors, Tumor Necrosis Factor, Type I / genetics
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Receptors, Tumor Necrosis Factor, Type I / immunology
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Receptors, Tumor Necrosis Factor, Type I / metabolism
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Receptors, Tumor Necrosis Factor, Type I / physiology*
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Signal Transduction
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Sphingomyelin Phosphodiesterase / metabolism*
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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Receptors, Tumor Necrosis Factor, Type I
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Tnfrsf1a protein, mouse
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Tumor Necrosis Factor-alpha
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Sphingomyelin Phosphodiesterase