Long-term outcome of living donors older than 60 years

Abstract

Long-term outcomes of renal transplantation using kidneys from donors >60 years old are generally considered to be poor. This retrospective study included 265 living donor (LD) transplants in adult recipients with a mean follow-up of 13.1 +/- 6.1 years (range, 1.3-25.8), all of them under CNI. They were grouped according to the donor age at least (n = 49) or less (n = 216) than 60 years. Graft and patient survivals were compared using the Kaplan-Meier method and Cox multiple regression. At 1, 3, and 10 years, postoperatively patient survivals in the group of older LD recipients were 97%, 96%, and 93%, versus 98%, 97% and 92% among the younger LD recipients. At 1, 3 and 10 years, postoperatively graft survivals uncensored for death were 94%, 92%, and 81% among the older LD recipients versus 93%, 89%, 75% among the control group, respectively, despite a slightly increased creatininemia observed at 10 years among the older LD recipients. Deaths censored graft survivals were 96%, 96%, and 87% among the older versus 94%, 91% and 78% among the younger LD recipients, respectively. Therefore, significantly better noncensored death-censored graft survivals, were observed among the recipients of older LD compared with recipients of the younger donor group.