Detection of "Candidatus Neoehrlichia mikurensis" in two patients with severe febrile illnesses: evidence for a European sequence variant

J Clin Microbiol. 2010 Jul;48(7):2630-5. doi: 10.1128/JCM.00588-10. Epub 2010 Jun 2.

Abstract

Recently, a new genus of Anaplasmataceae termed "Candidatus Neoehrlichia" was discovered in ticks and rodents. Here, we report on two patients who suffered from febrile bacteremia due to "Candidatus Neoehrlichia mikurensis" associated with thrombotic or hemorrhagic events. 16S rRNA and groEL gene sequencing provided evidence of three groups of sequence variants.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anaplasmataceae / genetics
  • Anaplasmataceae / isolation & purification*
  • Anaplasmataceae Infections / diagnosis
  • Anaplasmataceae Infections / drug therapy
  • Anaplasmataceae Infections / microbiology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteremia / diagnosis
  • Bacteremia / drug therapy
  • Bacteremia / microbiology
  • Bone Marrow / microbiology
  • DNA, Bacterial / chemistry
  • Europe
  • Fatal Outcome
  • Fever / microbiology*
  • Genes, Bacterial / genetics
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Phylogeny
  • Polymerase Chain Reaction
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA
  • Tick-Borne Diseases / diagnosis
  • Tick-Borne Diseases / drug therapy
  • Tick-Borne Diseases / microbiology

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • RNA, Ribosomal, 16S

Associated data

  • GENBANK/EU810404
  • GENBANK/EU810405
  • GENBANK/EU810406
  • GENBANK/EU810407
  • GENBANK/GU212868