Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis

Chew-Yan Gan; Tadahiro Etoh; Masahiko Hayashi; Kanki Komiyama; Toh-Seok Kam

doi:10.1021/np1001187

Leucoridines A-D, cytotoxic Strychnos-Strychnos bisindole alkaloids from Leuconotis

J Nat Prod. 2010 Jun 25;73(6):1107-11. doi: 10.1021/np1001187.

Authors

Chew-Yan Gan¹, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam

Affiliation

¹ Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

PMID: 20515042
DOI: 10.1021/np1001187

Abstract

Four new bisindole alkaloids of the Strychnos-Strychnos type, leucoridines A-D (1-4), were isolated from the stem-bark extract of Leuconotis griffithii. Alkaloids 1-4 showed moderate cytotoxicity against drug-sensitive and vincristine-resistant human KB cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology*
Apocynaceae / chemistry*
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids / chemistry
Indole Alkaloids / isolation & purification*
Indole Alkaloids / pharmacology*
KB Cells
Malaysia
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Plants, Medicinal / chemistry*
Strychnos / chemistry*
Vincristine / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
Vincristine