Considerable interest experimental and clinical researches has been focused on important role of advanced glication and its products and oxidative stress on the structure and functional disorders of platelets in diabetes. The aim of the study of our work was an estimate of platelet count (PLT) and mean platelet volume (MPV) for diabetics and control subjects and diabetics depending on glycated haemoglobin. In patients with type 2 diabetes mellitus, the platelet count was 216.4 x 10(9)/l in control subjects 223.60 x 10(9)/l. The mean platelet volume in diabetic was significantly higher than in control subjects and the results totaled 9.81 fl in diabetics. The platelet count in groups: B1 and B2 than in control subjects 9.36 fl, depending on glycated haemoglobin were not significantly important. The mean platelet volume in diabetics with level of glycated haemoglobin below 7.5% was 10.25 fl in group B2 9.83 fl and in control subjects 9.36 fl. One can suppose changes in patelet count and mean platelet volume depend on level metabolic disorders in diabetic.