New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity

Amany E Ragab; Sabine Grüschow; Emma J Rackham; Rebecca J M Goss

doi:10.1039/c003964k

New pacidamycins biosynthetically: probing N- and C-terminal substrate specificity

Org Biomol Chem. 2010 Jul 21;8(14):3128-9. doi: 10.1039/c003964k. Epub 2010 Jun 1.

Authors

Amany E Ragab¹, Sabine Grüschow, Emma J Rackham, Rebecca J M Goss

Affiliation

¹ The School of Chemistry, University of East Anglia, Norwich, UK NR4 7TJ.

PMID: 20514371
DOI: 10.1039/c003964k

Abstract

Feeding phenylalanine analogues to Streptomyces coeruleorubidus reveals the remarkable steric and electronic flexibility of this biosynthetic pathway and leads to the generation of a series of new halopacidamycins.

MeSH terms

Anti-Bacterial Agents / biosynthesis*
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / metabolism
Isomerism
Peptides / chemistry*
Peptides / metabolism*
Pyrimidine Nucleosides / biosynthesis
Pyrimidine Nucleosides / chemistry*
Pyrimidine Nucleosides / metabolism*
Streptomyces / metabolism
Substrate Specificity

Substances

Anti-Bacterial Agents
Peptides
Pyrimidine Nucleosides