The assessment of micropollutants in the urban aquatic environment is a challenging task since both the water balance and the contaminant concentrations are characterized by a pronounced variability in time and space. In this study the water balance of a central European urban drainage catchment is quantified for a period of one year. On the basis of a concentration monitoring of several micropollutants, a contaminant mass balance for the study area's wastewater, surface water, and groundwater is derived. The release of micropollutants from the catchment was mainly driven by the discharge of the wastewater treatment plant. However, combined sewer overflows (CSO) released significant loads of caffeine, bisphenol A, and technical 4-nonylphenol. Since an estimated fraction of 9.9-13.0% of the wastewater's dry weather flow was lost as sewer leakages to the groundwater, considerable loads of bisphenol A and technical 4-nonylphenol were also released by the groundwater pathway. The different temporal dynamics of release loads by CSO as an intermittent source and groundwater as well as treated wastewater as continuous pathways may induce acute as well as chronic effects on the receiving aquatic ecosystem. This study points out the importance of the pollution pathway CSO and groundwater for the contamination assessments of urban water resources.