Interactive Audience Response Systems (ARS) are widely used as tools to promote active learning in the classroom in many disciplines. Researchers have found that ARS technology with question-driven instruction (QDI) makes classroom instruction more student centered, while creating an environment for active learning. The purpose of this study was to evaluate the effect of ARS with QDI in one bachelors of science in nursing course on the perceived learning experience of the students. ARS technology with QDI was used in a beginning medical-surgical class of junior-level students throughout one semester. Descriptive statistical analyses indicated that nursing students positively evaluated the effect of ARS with QDI on their learning. Qualitative analyses indicated that students had better understanding of the material via post-question discussion of the rationales for answers, enhanced NCLEX-RN preparation, and increased interactivity, which led to paying more attention in class.