Abstract
A series of benzothiazole derivatives including N-(benzo[d]thiazol-2-yl)cyclohexanecarboxamides (2a-g) and N-(benzo[d]thiazol-2-yl)cyclohexancarbothioamides (3b-d) have been synthesized and evaluated for cytotoxic and antimicrobial activities. Two compounds including N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarboxamide (2c) and N-(6-ethoxybenzo[d]thiazol-2-yl)cyclohexanecarbothiamide (3c) demonstrated significant cytotoxicity against three cancer cell lines (A549, MCF7-MDR and HT1080) while most of compounds exhibited moderate inhibitory effects on the growth of Staphyllococcus aureus and some other fungi.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemical synthesis
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Aspergillus niger / drug effects
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Bacillus subtilis / drug effects
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Benzothiazoles / chemical synthesis*
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Benzothiazoles / pharmacology*
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Candida albicans / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Drug Evaluation, Preclinical
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Escherichia coli / drug effects
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Fusarium / drug effects
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Humans
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Inhibitory Concentration 50
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Microbial Sensitivity Tests
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Pseudomonas aeruginosa / drug effects
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Saccharomyces cerevisiae / drug effects
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Staphylococcus aureus / drug effects*
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Benzothiazoles
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N-(6-ethoxybenzo(d)thiazol-2-yl)cyclohexanecarbothiamide
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N-(6-ethoxybenzo(d)thiazol-2-yl)cyclohexanecarboxamide