p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN

Cell Cycle. 2010 Jun 1;9(11):2055-6. doi: 10.4161/cc.9.11.11926. Epub 2010 Jun 1.
No abstract available

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Class Ia Phosphatidylinositol 3-Kinase / metabolism*
  • Class Ia Phosphatidylinositol 3-Kinase / physiology
  • Humans
  • Inositol Phosphates / metabolism
  • PTEN Phosphohydrolase / metabolism*
  • Protein Subunits / metabolism
  • Protein Subunits / physiology
  • Proto-Oncogene Proteins c-akt / metabolism
  • Signal Transduction

Substances

  • Inositol Phosphates
  • Protein Subunits
  • inositol 3,4,5-trisphosphate
  • Class Ia Phosphatidylinositol 3-Kinase
  • Proto-Oncogene Proteins c-akt
  • PTEN Phosphohydrolase
  • PTEN protein, human