Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults characterized by high viral genome load within circulating natural killer cells

C P Fox; C Shannon-Lowe; P Gothard; B Kishore; J Neilson; N O'Connor; M Rowe

doi:10.1086/653424

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in adults characterized by high viral genome load within circulating natural killer cells

Clin Infect Dis. 2010 Jul 1;51(1):66-9. doi: 10.1086/653424.

Authors

C P Fox¹, C Shannon-Lowe, P Gothard, B Kishore, J Neilson, N O'Connor, M Rowe

Affiliation

¹ School of Cancer Sciences, University of Birmingham, Edgbaston, UK. c.p.fox@bham.ac.uk

PMID: 20504238
DOI: 10.1086/653424

Abstract

Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease usually encountered in the context of primary EBV infection. In most analyzed cases, EBV has been found predominantly in T cells. We describe the novel finding of high EBV genome numbers within circulating natural killer cells in adult patients with EBV-HLH.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow Examination
Epstein-Barr Virus Infections / complications*
Genome, Viral
Herpesvirus 4, Human / genetics
Herpesvirus 4, Human / isolation & purification*
Humans
Killer Cells, Natural / virology*
Lymphohistiocytosis, Hemophagocytic / virology*
Male
Middle Aged
Retrospective Studies
Viral Load
Young Adult