Realistic modeling of soft tissue deformation is crucial to virtual orthopedic surgery, especially orthopedic trauma surgery which involves layered heterogeneous soft tissues. In this paper, a novel modeling framework for multilayered soft tissue deformation is proposed in order to facilitate the development of orthopedic surgery simulators. We construct our deformable model according to the layered structure of real human organs, and this results in a multilayered model. The division of layers is based on the segmented Chinese Visible Human (CVH) dataset. This enhances the realism and accuracy in the simulation. For the sake of efficiency, we employ 3D mass-spring system to our multilayered model. The nonlinear passive biomechanical properties of skin and skeletal muscle are achieved by introducing a bilinear elasticity scheme to the springs in the mass-spring system. To efficiently and accurately reproduce the biomechanical properties of certain human tissues, an optimization approach is employed in configuring the parameters of the springs. Experimental data from biomechanics literatures are used as benchmarking references. With the employment of Physics Processing Unit (PPU) and high quality volume visualization, our framework is developed into an interactive and intuitive platform for virtual surgery training systems. Several experiments demonstrate the feasibility of the proposed framework in providing interactive and realistic deformation for orthopedic surgery simulation.