The fusion of multimodal medical images plays an important role in many clinical applications as it can support more accurate information than any individual source image. This paper presents a novel approach for fusion of computed tomography (CT) and magnetic resonance (MR) images based on wavelet transform. The medical images to be fused are firstly decomposed into multiscale representations by the wavelet transform. Then, by considering the physical meaning of wavelet coefficients and the characteristics of the CT and MR images, the coefficients of the low frequency band and high frequency bands are treated with different schemes: the former is performed with a maximum-selection (MS) rule, and the latter is convolved with a Laplacian operator followed by a MS rule. Finally, the fused image is reconstructed by using the inverse wavelet transform with the combined wavelet coefficients. The performance of our method is qualitatively and quantitatively compared with some existing fusion approaches. The experimental results can demonstrate that the proposed method is a promising and effective technique for fusion of CT and MR images.