Structure-activity analysis of the Pseudomonas quinolone signal molecule

J Bacteriol. 2010 Jul;192(14):3833-7. doi: 10.1128/JB.00081-10. Epub 2010 May 21.

Abstract

We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Regulation, Bacterial / drug effects
  • Molecular Structure
  • Oligopeptides / genetics
  • Oligopeptides / metabolism
  • Pseudomonas / drug effects*
  • Pseudomonas / metabolism*
  • Quinolones / chemistry*
  • Quinolones / metabolism
  • Quinolones / pharmacology*
  • Structure-Activity Relationship

Substances

  • 2-heptyl-3-hydroxy-4-quinolone
  • Oligopeptides
  • Quinolones
  • pyoverdin