The problem of a comprehensive evaluation of the influence of major vital factors on the health of schoolchildren and students has been recently pressing. The paper contains the material obtained in the development of a comprehensive approach to the hygienic assessment of quality of life (QL) in pupils and young students. The findings enable one to state the fundamentals of the concept of a comprehensive approach to assessing QL in pupils, to introduce a new principle in the comparison of objective parameters with subjective ones, to prove the dynamics and variability of QL characteristics. The obtained material substantiates the need for theoretical and practical developments of this problem.