Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis

Juliette Mazereeuw-Hautier; Peter H Hoeger; Sarah Benlahrech; Amir Ammour; Pierre Broue; Julie Vial; Gerard Ohanessian; Christine Léauté-Labrèze; Marc Labenne; Pierre Vabres; Jochen Rössler; Christine Bodemer

doi:10.1016/j.jpeds.2010.04.003

Efficacy of propranolol in hepatic infantile hemangiomas with diffuse neonatal hemangiomatosis

J Pediatr. 2010 Aug;157(2):340-2. doi: 10.1016/j.jpeds.2010.04.003. Epub 2010 May 20.

Authors

Juliette Mazereeuw-Hautier¹, Peter H Hoeger, Sarah Benlahrech, Amir Ammour, Pierre Broue, Julie Vial, Gerard Ohanessian, Christine Léauté-Labrèze, Marc Labenne, Pierre Vabres, Jochen Rössler, Christine Bodemer

Affiliation

¹ Dermatology Department, Paul Sabatier University and the Department of Dermatology, Children's Hospital, Toulouse, France. mazereeuw-hautier.j@chu-toulouse.fr

PMID: 20488455
DOI: 10.1016/j.jpeds.2010.04.003

Abstract

We report the rapid and dramatic efficacy of propranolol in 8 infants with infantile hepatic hemangiomas. The degree of response varied from a significant improvement to a complete resolution of hepatic lesions. Heart failure and hypothyroidism resolved, and hepatomegaly decreased. No side-effects of the drug were noted.

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Female
Heart Failure / prevention & control
Hemangioma / drug therapy*
Humans
Infant
Liver Neoplasms / drug therapy*
Male
Propranolol / pharmacology
Propranolol / therapeutic use*
Skin Neoplasms / drug therapy*
Treatment Outcome
Vasodilator Agents / therapeutic use

Substances

Adrenal Cortex Hormones
Vasodilator Agents
Propranolol