Synthesis and antifungal activities of new pyrazole derivatives via 1,3-dipolar cycloaddition reaction

Chem Biol Drug Des. 2010 May;75(5):489-93. doi: 10.1111/j.1747-0285.2010.00948.x.

Abstract

A series of cycloadducts--pyrazoles via 1,3-dipolar cycloaddition reactions of generated nitrilimines with N-(4-chloro-2-fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by (1)H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title compounds exhibit significant fungicidal activities against Corynespora cassiicola.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Crystallography, X-Ray
  • Cyclization
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Pyrazoles