Abstract
Long-term exposure to arsenic has been linked to the development of numerous cutaneous neoplasms including arsenical keratoses, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs). We report a patient with a remote history of psoriasis treated with arsenic who subsequently developed more than 40 nonmelanoma skin cancers as well as arsenical keratoses. This patient had a remarkable response to imiquimod cream 5% applied once daily to affected areas for 6 weeks with complete resolution of all cutaneous neoplasms and no evidence of recurrence in more than 3 years of clinical surveillance.
MeSH terms
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Administration, Cutaneous
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Aged, 80 and over
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Aminoquinolines / administration & dosage
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Aminoquinolines / therapeutic use*
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Arsenic / adverse effects*
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Arsenic / therapeutic use
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Carcinoma, Squamous Cell / chemically induced
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Carcinoma, Squamous Cell / drug therapy
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Follow-Up Studies
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Humans
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Imiquimod
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Keratosis / chemically induced
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Keratosis / drug therapy
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Male
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Neoplasm Recurrence, Local / prevention & control
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Psoriasis / drug therapy
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Skin Neoplasms / chemically induced
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Skin Neoplasms / drug therapy*
Substances
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Aminoquinolines
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Antineoplastic Agents
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Arsenic
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Imiquimod