Abstract
Platencin is a novel antibiotic which is active against multiresistant pathogens. We describe efficient syntheses of three platencin analogues of varying activities which allow further conclusions about the pharmacophoric part of the molecule. The unnatural antibiotic iso-platencin, which is about as active as natural platencin, but much more selective, was identified as a new lead structure.
MeSH terms
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Aminophenols / chemical synthesis*
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Aminophenols / chemistry*
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry*
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Chlorides / chemical synthesis*
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Chlorides / chemistry*
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Microbial Sensitivity Tests
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Molecular Structure
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Polycyclic Compounds / chemical synthesis*
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Polycyclic Compounds / chemistry*
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Stereoisomerism
Substances
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Aminophenols
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Anti-Bacterial Agents
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Chlorides
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Polycyclic Compounds
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platencin