Pterosins from Pteris multifida

Planta Med. 2010 Nov;76(16):1896-900. doi: 10.1055/s-0030-1249934. Epub 2010 May 19.

Abstract

A new C(14) pterosin sesquiterpenoid, named (2R)-pterosin P (1), and a new natural product, named dehydropterosin B (3), were isolated from the aerial parts of Pteris multifida Poir., along with nine known compounds (2, 4-11). By chiral HPLC, compounds 1 and 2 were isolated as a pair of enantiomeric pterosin sesquiterpenoids. The planar structure of 1 was elucidated on the basis of NMR spectroscopy analysis, and the absolute configuration was established by the CD spectrum. In addition, the absolute structure of 1 was further confirmed by single-crystal X-ray diffraction (CuK α). Compounds 3, 5, and 6 showed potent cytotoxicity against PANC-1 (human pancreatic cancer) and NCI-H446 (human small-cell lung cancer) cell lines, with IC(50) values in the range of 4.27-14.63 µM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antineoplastic Agents, Phytogenic / therapeutic use
  • Cell Line, Tumor
  • Humans
  • Indans / isolation & purification*
  • Indans / pharmacology
  • Indans / therapeutic use
  • Inhibitory Concentration 50
  • Molecular Structure
  • Pancreatic Neoplasms / drug therapy*
  • Phytotherapy*
  • Plant Components, Aerial
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Pteris / chemistry*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use
  • Small Cell Lung Carcinoma / drug therapy*

Substances

  • (2R)-pterosin P
  • Antineoplastic Agents, Phytogenic
  • Indans
  • Plant Extracts
  • Sesquiterpenes
  • dehydropterosin B