Feline lectin activity is critical for the cellular entry of feline infectious peritonitis virus

J Virol. 2010 Aug;84(15):7917-21. doi: 10.1128/JVI.00964-10. Epub 2010 May 19.

Abstract

Feline infectious peritonitis is a lethal disease of felids caused by systemic infection with a feline coronavirus. Here, we report identification and analysis of the feline homologue to the human lectin DC-SIGN and show that it is a coreceptor for virulent strains of serotype 1 and serotype 2 feline coronaviruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cats
  • Cluster Analysis
  • Coronavirus, Feline / physiology*
  • Host-Pathogen Interactions*
  • Humans
  • Lectins, C-Type / genetics
  • Lectins, C-Type / metabolism*
  • Molecular Sequence Data
  • Phylogeny
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism*
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Virus Attachment*
  • Virus Internalization*

Substances

  • Lectins, C-Type
  • Receptors, Cell Surface

Associated data

  • GENBANK/HM237358