Abstract
The new cerebroside 1-O-(β-D-glucopyranosyl)-(2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxytetracosenoilamino]-8-octadecene-1,3,4-triol (1) and ceramide (2S, 3S, 4R, 8E)-2-[(2'R)-2'-hydroxytetracosenoilamino]-8-octadecene-1,3,4-triol (2) were isolated from the ethyl acetate extract of the pollen of Brassica napus L. The structures of 1 and 2 were elucidated on the basis of chemical and spectroscopic method. Two new compounds were evaluated for activity in vitro assays for the cytotoxic activities against human tongue squamous carcinoma cell line (Tca8113).
Copyright © 2010 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Brassica napus / chemistry*
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Carcinoma, Squamous Cell / drug therapy*
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Cell Line, Tumor
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Ceramides / chemistry
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Ceramides / isolation & purification
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Ceramides / therapeutic use*
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Cerebrosides / chemistry
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Cerebrosides / isolation & purification
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Cerebrosides / therapeutic use*
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Humans
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Molecular Structure
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / therapeutic use
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Pollen / chemistry
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Tongue Neoplasms / drug therapy*
Substances
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Antineoplastic Agents, Phytogenic
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Ceramides
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Cerebrosides
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Plant Extracts