Iron-mediated direct Suzuki-Miyaura reaction: a new method for the ortho-arylation of pyrrole and pyridine

Org Lett. 2010 Jun 18;12(12):2694-7. doi: 10.1021/ol100838m.

Abstract

The first example of an iron-mediated direct Suzuki-Miyaura reaction between N-heterocyclic compounds and arylboronic acids is described, and both electron-rich and electron-deficient heteroarenes can be successfully used for the coupling reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Heterocyclic Compounds / chemistry*
  • Iron / chemistry*
  • Molecular Structure
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Pyrroles / chemistry*
  • Stereoisomerism

Substances

  • Boronic Acids
  • Heterocyclic Compounds
  • Pyridines
  • Pyrroles
  • Iron