Abstract
The authors studied distribution of biochemical markers for HP, GC, EsD, AcP genes, polymorphism of GSTT1 (GST-theta 1), GSTM1 (GST-mu 1), locus WNTR of NOS3 gene (alleles A/B) in chronic dust bronchitis patients and in apparently healthy individuals. Genotypes EsD 1-2 and AcP bb individuals were proved to be most prone to the disease. Endogenous resistent factors for chronic dust bronchitis are genotypes GC 1-1, EsD 1-1, AcP bc.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Acid Phosphatase / blood
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Adult
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Biomarkers / blood*
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Bronchitis, Chronic / blood*
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Bronchitis, Chronic / epidemiology
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Bronchitis, Chronic / genetics
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Carboxylesterase / blood
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Coal
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Coal Mining*
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Dust
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Genetic Predisposition to Disease
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Genotype
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Haptoglobins / metabolism
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Humans
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Middle Aged
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Occupational Diseases / blood*
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Occupational Diseases / epidemiology
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Occupational Diseases / genetics
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Occupational Exposure / adverse effects*
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Polymorphism, Genetic
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Prevalence
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Siberia / epidemiology
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Vitamin D-Binding Protein / blood
Substances
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Biomarkers
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Coal
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Dust
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Haptoglobins
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Vitamin D-Binding Protein
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Carboxylesterase
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ESD protein, human
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Acid Phosphatase