Viral defense: it takes two MAVS to Tango

Shruti Sharma; Katherine A Fitzgerald

doi:10.1016/j.cell.2010.04.043

Viral defense: it takes two MAVS to Tango

Cell. 2010 May 14;141(4):570-2. doi: 10.1016/j.cell.2010.04.043.

Authors

Shruti Sharma¹, Katherine A Fitzgerald

Affiliation

¹ Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

PMID: 20478250
DOI: 10.1016/j.cell.2010.04.043

Abstract

To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiviral genes that curb viral replication until mitochondrial MAVS can induce a sustained antiviral response.

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