The relation between disordered eating and substance use was examined among Mexican female adolescents in a probabilistic sample of 2537 high school students in central Mexico, stratified by marginalization status and migratory intensity, obtained during 2006 ?2007 school year. The Brief Disordered Eating Questionnaire and the World Health Organization and United Nations Division of Narcotic Drugs recommendations for substance use assessments were used. Prevalence and odds ratios for disordered eating and substance use items were calculated separately across low and high marginalization groups. Study's implications and limitations are noted, as well as future research and prevention strategies are suggested.