Nucleosome positioning: an essential component of the enhancer regulatory code?

Ahmet Ay; David N Arnosti

doi:10.1016/j.cub.2010.03.051

Nucleosome positioning: an essential component of the enhancer regulatory code?

Curr Biol. 2010 May 11;20(9):R404-6. doi: 10.1016/j.cub.2010.03.051.

Authors

Ahmet Ay¹, David N Arnosti

Affiliation

¹ Department of Biochemistry and Molecular Biology, and Program in Quantitative Biology, Michigan State University, East Lansing, MI 48824, USA. ayahmet@msu.edu

PMID: 20462481
DOI: 10.1016/j.cub.2010.03.051

Abstract

The organization of transcription factor binding sites within enhancers plays a key role in the function of these elements. A recent study suggests that the intrinsic propensity to bind to nucleosomes can also play a decisive part in determining enhancer function.

Publication types

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MeSH terms

Animals
Ciona intestinalis / genetics
Enhancer Elements, Genetic / physiology*
GATA Transcription Factors / physiology
Gene Expression Regulation / genetics
Gene Expression Regulation / physiology
Nucleosomes / physiology*
Transcription Factors / physiology

Substances

GATA Transcription Factors
Nucleosomes
Transcription Factors