Novoamauromine and ent-Cycloechinulin: two new diketopiperazine derivatives from Aspergillus novofumigatus

Chem Pharm Bull (Tokyo). 2010 May;58(5):717-9. doi: 10.1248/cpb.58.717.

Abstract

Two new diketopiperazine metabolites, novoamauromine (1) and ent-cycloechinulin (2) have been isolated from Aspergillus novofumigatus CBS117520. The structures of 1 and 2 were established on the basis of spectroscopic and chemical investigation, including a detailed comparison of the spectroscopic and physico-chemical data of amauromine (3) and cycloechinulin (4).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents* / chemistry
  • Antifungal Agents* / pharmacology
  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Aspergillus / chemistry*
  • Cell Line, Tumor
  • Chromatography, Liquid
  • Diketopiperazines / chemistry*
  • Fungi / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Molecular Structure

Substances

  • Antifungal Agents
  • Antineoplastic Agents
  • Diketopiperazines
  • ent-cycloechinulin
  • novoamauromine