Abstract
Three new 12-hydroxybriarane diterpenoids, excavatoids L-N (1-3), have been isolated from the cultured octocoral Briareum excavatum. The structures of new briaranes 1-3 were elucidated by the interpretations of spectroscopic methods. Excavatoid L (1) displayed moderate inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Biological Products / chemistry*
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Gene Expression Regulation / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neutrophils / drug effects*
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Pancreatic Elastase / metabolism
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Superoxides / antagonists & inhibitors
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Superoxides / metabolism
Substances
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Biological Products
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Diterpenes
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excavatoid L
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excavatoid M
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excavatoid N
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Superoxides
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Pancreatic Elastase