Excavatoids L-N, new 12-hydroxybriaranes from the cultured octocoral Briareum excavatum (Briareidae)

Chem Pharm Bull (Tokyo). 2010 May;58(5):662-5. doi: 10.1248/cpb.58.662.

Abstract

Three new 12-hydroxybriarane diterpenoids, excavatoids L-N (1-3), have been isolated from the cultured octocoral Briareum excavatum. The structures of new briaranes 1-3 were elucidated by the interpretations of spectroscopic methods. Excavatoid L (1) displayed moderate inhibitory effects on superoxide anion generation and elastase release by human neutrophils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Biological Products / chemistry*
  • Biological Products / isolation & purification
  • Biological Products / pharmacology*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Gene Expression Regulation / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neutrophils / drug effects*
  • Pancreatic Elastase / metabolism
  • Superoxides / antagonists & inhibitors
  • Superoxides / metabolism

Substances

  • Biological Products
  • Diterpenes
  • excavatoid L
  • excavatoid M
  • excavatoid N
  • Superoxides
  • Pancreatic Elastase