Inhibition by genistein of the lipopolysaccharide-induced down-regulation of programmed cell death 4 in RAW 264.7 mouse macrophages

Biosci Biotechnol Biochem. 2010;74(5):1095-7. doi: 10.1271/bbb.90892. Epub 2010 May 7.

Abstract

Programmed cell death 4 (Pdcd4), a novel tumor suppressor, has recently emerged as an anti-inflammatory protein. We assessed in the present study the effects of 18 different food factors with anti-inflammatory activity on the lipopolysaccharide-induced down-regulation of pdcd4 mRNA expression in mouse RAW 264.7 macrophages. Genistein, a soy isoflavone, significantly inhibited pdcd4 down-regulation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Apoptosis Regulatory Proteins / genetics
  • Cell Death / drug effects*
  • Cell Line
  • Down-Regulation / drug effects*
  • Food
  • Genistein / pharmacology*
  • Lipopolysaccharides / pharmacology*
  • Macrophages / cytology*
  • Macrophages / drug effects
  • Macrophages / metabolism*
  • Mice
  • Plant Extracts / pharmacology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics

Substances

  • Anti-Inflammatory Agents
  • Apoptosis Regulatory Proteins
  • Lipopolysaccharides
  • Pdcd4 protein, mouse
  • Plant Extracts
  • RNA, Messenger
  • RNA-Binding Proteins
  • Genistein