Abstract
Programmed cell death 4 (Pdcd4), a novel tumor suppressor, has recently emerged as an anti-inflammatory protein. We assessed in the present study the effects of 18 different food factors with anti-inflammatory activity on the lipopolysaccharide-induced down-regulation of pdcd4 mRNA expression in mouse RAW 264.7 macrophages. Genistein, a soy isoflavone, significantly inhibited pdcd4 down-regulation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Apoptosis Regulatory Proteins / genetics
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Cell Death / drug effects*
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Cell Line
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Down-Regulation / drug effects*
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Food
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Genistein / pharmacology*
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Lipopolysaccharides / pharmacology*
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Macrophages / cytology*
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Macrophages / drug effects
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Macrophages / metabolism*
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Mice
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Plant Extracts / pharmacology
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA-Binding Proteins / genetics
Substances
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Anti-Inflammatory Agents
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Apoptosis Regulatory Proteins
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Lipopolysaccharides
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Pdcd4 protein, mouse
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Plant Extracts
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RNA, Messenger
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RNA-Binding Proteins
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Genistein